The peptide that reinvented weight loss.
Superior Weight Reduction
Metabolic Improvement
Appetite Suppression
Made in USA
LAB CERTIFIED
SHIPS FROM USA
PREMIUM QUALITY
SIGNIFICANT WEIGHT REDUCTION
KIDNEY DISEASE BENEFITS
LIVER FAT REDUCTION
PRESERVES MUSCLE
LAB CERTIFIED
SHIPS FROM USA
PREMIUM QUALITY
SIGNIFICANT WEIGHT REDUCTION
KIDNEY DISEASE BENEFITS
LIVER FAT REDUCTION
PRESERVES MUSCLE
the next generation of metabolic Health
the next generation of metabolic Health
%
Average body weight reduction. The highest ever recorded in a late-stage obesity trial
%
Average body weight reduction. The highest ever recorded in a late-stage obesity trial
lbs
Average weight lost by users. More than any weight loss drug ever studied.
lbs
Average weight lost by users. More than any weight loss drug ever studied.
%
Achieved normal liver fat levels at 48 weeks. Fatty liver disease reversed.
%
Achieved normal liver fat levels at 48 weeks. Fatty liver disease reversed.
x
Hormonal pathways targeted simultaneously: GLP-1, GIP, and Glucagon receptors
x
Hormonal pathways targeted simultaneously: GLP-1, GIP, and Glucagon receptors
Excess weight is widely recognized by medical bodies as a chronic condition with a strong biological and hormonal component. Retatrutide works by supporting the correction of hormonal signals involved in appetite regulation, energy expenditure, and glucose control, as demonstrated in published clinical research.
Excess weight is widely recognized by medical bodies as a chronic condition with a strong biological and hormonal component. Retatrutide works by supporting the correction of hormonal signals involved in appetite regulation, energy expenditure, and glucose control, as demonstrated in published clinical research.
clinical applications
clinical applications
Obesity & Weight Management
Obesity & Weight Management
Blood Sugar & Glycemic Health
Blood Sugar & Glycemic Health
Liver Fat & Metabolic Health
Liver Fat & Metabolic Health
Diabetic Kidney Disease
Diabetic Kidney Disease
explore our top researched peptide
Retatrutide
Starting at $285
Research Peptide (GLP-1/GLP-3) LY34379
Formula: C₂₂₁H₃₄₂N₄₆O₆₈
Batch Verified
NO ENDOTOXIN DETECTED
10mg
20mg
30mg
Over 99% Purity verified by independent third-party HPLC/UV/MS
Third-party lab tested
Lyophilized peptide format (research vials)
Mannitol-free (no bulking agents or buffers)
Certificate of Analysis
MADE IN USA
Specifications
Product Name: GLP-3 Quantity: 10/20/30mg (Lyophilized Powder) CAS #: Molecular Formula: C₂₂₃H₃₄₃F₃N₄₆O₇₀ Confirmed Molecular Weight (MS): 4728.48 Da Purity (HPLC): 99.6% Method of Analysis: HPLC-UV-MS Manufactured In: USA
Purity Testing
High Performance Liquid Chromatography (HPLC-UV) testing confirms: • Purity: 99.6% • Minimal secondary peak detection • Lot-specific Certificate of Analysis available
Packaging
• Sterile sealed vial • Lyophilized powder • Clearly labeled lot number • Stored under controlled conditions
Compliance statement: This product is intended strictly for laboratory research, analytical testing, and scientific investigation. Not for human consumption. Not for therapeutic or diagnostic use. For research use only.
Three hormonal Targets, one peptide.
Three hormonal Targets, one peptide.
Think of your metabolism like a lock with three keys. Most weight loss drugs only carry one. Retatrutide carries all three. Retatrutide simultaneously engages GLP-1, GIP, and glucagon receptors. The first in the world.
Think of your metabolism like a lock with three keys. Most weight loss drugs only carry one. Retatrutide carries all three. The first in the world.
GLP-1 Receptor Activation
Stimulates insulin release, decreases glucagon secretion, reduces food intake, and delays gastric emptying. GLP-1 receptors are distributed across the pancreas, brain, heart, kidneys, and gut — producing wide-ranging metabolic benefits.
Insulin & appetite control
Suppresses brain hunger signals
Stabilizes blood sugar
Slow digestion keeps you full longer
GIP Receptor Activation
Works in tandem with GLP-1 to enhance insulin secretion and reduce appetite. GIP agonism also influences bone metabolism and adipose tissue, inhibiting fat storage while promoting better lipid handling.
Amplified response & tolerability
Amplify the body's insulin response
Enhances how efficiently fat is stored and released
Deepens appettite-supressing effect of GLP-1
Glucagon Receptor Activation
Promotes energy expenditure, reduces lipogenesis, induces lipolysis, and reduces GI motility. Glucagon receptor action drives fat burning from the liver and adipose tissue, directly amplifying weight loss beyond what GLP-1 alone achieves.
Metabolic acceleration
Drives the liver to burn stored fat for fuel
Raises your metabolic rate
Keeps fat loss active between meals
unmatched in all metrics
unmatched in
All metrics
METRIC
METRIC
OZEMPIC
OZEMPIC
MOUNJARO
MOUNJARO
RETATRUTIDE
Receptors Targeted
Receptors
Targeted
1 (GLP-1)
1 (GLP-1)
2 (GLP-1, GIP)
2 (GLP-1, GIP)
3 (GLP-1, GIP, Glucagon)
3 (GLP-1, GIP, Glucagon)
Avg. Weight Loss (Max Dose)
Avg. Weight Loss (Max Dose)
15% (68 weeks)
15% (68 weeks)
22.5% (72 weeks)
22.5% (72 weeks)
28.7% (68 weeks, Phase 3)
28.7% (68 weeks, Phase 3)
Average Pounds Lost
Average Pounds Lost
34 lbs
34 lbs
48 lbs
48 lbs
71 lbs (Phase 3)
71 lbs (Phase 3)
Fat Burning (Metabolism)
Fat Burning (Metabolism)
Appetite Only
Appetite Only
Appetite + Insulin
Appetite + Insulin
Appetite + Insulin + Direct Fat Burn
Appetite + Insulin
+ Direct Fat Burn
Appetite + Insulin + Direct Fat Burn
Liver Fat Reduction
Liver Fat Reduction
Moderate
Moderate
Significant
Significant
93% Achieve Normal Liver Fat
93% Achieve Normal Liver Fat
Dosing Frequency
Dosing Frequency
Once Weekly
Once Weekly
Once Weekly
Once Weekly
Once Weekly
Once Weekly
Sources: STEP-1 (semaglutide), SURMOUNT-1 (tirzepatide), TRIUMPH-4 (retatrutide Phase 3, Dec 2025). Results vary by individual. All figures are from clinical trial populations.
Sources: STEP-1 (semaglutide), SURMOUNT-1 (tirzepatide), TRIUMPH-4 (retatrutide Phase 3, Dec 2025). Results vary by individual. All figures are from clinical trial populations.
ascend in weeks,
not years.
ascend in weeks,
not years.
Community Member
Over the past 5 months on Retatrutide (starting at 2mg/week and titrating up to 6mg now), combined with TRT, smart training, and a low-carb diet with weekly refeeds, I dropped from 20% body fat down to 8%.
Community Member
225 lbs -> 150 lbs
Reta is a game changer. Currently on 5mg/wk, titrated up from SD of 2mg/wk. I lift heavy 6x a week, cardio (treadmill @3.0-3.2, incline 8-12, 30-60 mins), track all food, eat in a deficit and hit around 120g of protein a day.
Community Member
205 lbs -> 117 lbs
I almost didn’t share these before and after photos because it feels really vulnerable to put this part of my life out there.
But I’m posting anyway because posts like this helped me to feel less alone and gave me hope that change was possible. I hope this may help someone else who is struggling as well.
Community Member
I honestly did not expect the difference in my face to be this noticeable. Through Retatrutide and losing weight, my face has changed a lot. For me, the change is even more obvious in my face than in many other parts of my body.
Community Member
Reta has changed the course of my life so drastically i'm still having a hard time grasping what happened in the last 10 months and where i'm going to take it! starting weight was 347Lbs current weight is 231lbs i struggled with depression, was on the verge of being diabetic and had an unhealthy relationship with food and alcohol. i'm excited to see what in store for me in the next couple months
Community Member
Over the past 5 months on Retatrutide (starting at 2mg/week and titrating up to 6mg now), combined with TRT, smart training, and a low-carb diet with weekly refeeds, I dropped from 20% body fat down to 8%.
Community Member
225 lbs -> 150 lbs
Reta is a game changer. Currently on 5mg/wk, titrated up from SD of 2mg/wk. I lift heavy 6x a week, cardio (treadmill @3.0-3.2, incline 8-12, 30-60 mins), track all food, eat in a deficit and hit around 120g of protein a day.
Community Member
205 lbs -> 117 lbs
I almost didn’t share these before and after photos because it feels really vulnerable to put this part of my life out there.
But I’m posting anyway because posts like this helped me to feel less alone and gave me hope that change was possible. I hope this may help someone else who is struggling as well.
Community Member
I honestly did not expect the difference in my face to be this noticeable. Through Retatrutide and losing weight, my face has changed a lot. For me, the change is even more obvious in my face than in many other parts of my body.
Community Member
Reta has changed the course of my life so drastically i'm still having a hard time grasping what happened in the last 10 months and where i'm going to take it! starting weight was 347Lbs current weight is 231lbs i struggled with depression, was on the verge of being diabetic and had an unhealthy relationship with food and alcohol. i'm excited to see what in store for me in the next couple months
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